Usability Experience in the Calculation of Pharmacokinetic Parameters with Software: Phenytoin Case

Stefhano Olivo Valdivia, Rita Nieto Montesinos, Karim Vera López, Gonzalo Dávila-Del-Carpio

Producción científica: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

Resumen

The objective of this research was to evaluate how the use of mathematical models that simulate the drug's pharmacokinetic, can influence the calculation of pharmacokinetic parameters, being the human-computer-interaction an useful tool to simplify them. For it, we study the effect of P-gp inhibitors on the pharmacokinetics of the anticonvulsant, phenytoin; we co-administered the drugs to a group of rats and then measured the plasma concentrations of phenytoin, from which we calculated the pharmacokinetic parameters, manually and using the WinNonlin software. P-gp inhibitors caused a change in the pharmacokinetics of phenytoin, moving from the open-one compartment model to the open-two-compartment model, this was demonstrated with a better fit of data (r = 0.9871) in the two compartments model. Since complex mathematical models are necessary, the software will be useful, but it is the pharmacokinetic specialists who evaluate and define the model to be used, which demonstrates the importance of HCI.

Idioma originalInglés
Título de la publicación alojadaCITIE 2020 - Proceedings of the 3rd Congreso Internacional de Tendencias en Innovacion Educativa 2020
EditoresKlinge Orlando Villalba-Condori, Jari Lavonen, Lung Hsiang Wong, Aman Yadav
EditorialCEUR-WS
Páginas143-154
Número de páginas12
ISBN (versión digital)9786124443275
EstadoPublicada - 2020
Evento3rd Congreso Internacional de Tendencias en Innovacion Educativa, CITIE 2020 - 3rd International Conference on Trends in Educational Innovation, CITIE 2020 - Arequipa, Perú
Duración: 9 dic. 202011 dic. 2020

Serie de la publicación

NombreCEUR Workshop Proceedings
Volumen3099
ISSN (versión impresa)1613-0073

Conferencia

Conferencia3rd Congreso Internacional de Tendencias en Innovacion Educativa, CITIE 2020 - 3rd International Conference on Trends in Educational Innovation, CITIE 2020
País/TerritorioPerú
CiudadArequipa
Período9/12/2011/12/20

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