TY - GEN
T1 - Usability Experience in the Calculation of Pharmacokinetic Parameters with Software
T2 - 3rd Congreso Internacional de Tendencias en Innovacion Educativa, CITIE 2020 - 3rd International Conference on Trends in Educational Innovation, CITIE 2020
AU - Valdivia, Stefhano Olivo
AU - Montesinos, Rita Nieto
AU - López, Karim Vera
AU - Dávila-Del-Carpio, Gonzalo
N1 - Publisher Copyright:
© 2020 for this paper by its authors.
PY - 2020
Y1 - 2020
N2 - The objective of this research was to evaluate how the use of mathematical models that simulate the drug's pharmacokinetic, can influence the calculation of pharmacokinetic parameters, being the human-computer-interaction an useful tool to simplify them. For it, we study the effect of P-gp inhibitors on the pharmacokinetics of the anticonvulsant, phenytoin; we co-administered the drugs to a group of rats and then measured the plasma concentrations of phenytoin, from which we calculated the pharmacokinetic parameters, manually and using the WinNonlin software. P-gp inhibitors caused a change in the pharmacokinetics of phenytoin, moving from the open-one compartment model to the open-two-compartment model, this was demonstrated with a better fit of data (r = 0.9871) in the two compartments model. Since complex mathematical models are necessary, the software will be useful, but it is the pharmacokinetic specialists who evaluate and define the model to be used, which demonstrates the importance of HCI.
AB - The objective of this research was to evaluate how the use of mathematical models that simulate the drug's pharmacokinetic, can influence the calculation of pharmacokinetic parameters, being the human-computer-interaction an useful tool to simplify them. For it, we study the effect of P-gp inhibitors on the pharmacokinetics of the anticonvulsant, phenytoin; we co-administered the drugs to a group of rats and then measured the plasma concentrations of phenytoin, from which we calculated the pharmacokinetic parameters, manually and using the WinNonlin software. P-gp inhibitors caused a change in the pharmacokinetics of phenytoin, moving from the open-one compartment model to the open-two-compartment model, this was demonstrated with a better fit of data (r = 0.9871) in the two compartments model. Since complex mathematical models are necessary, the software will be useful, but it is the pharmacokinetic specialists who evaluate and define the model to be used, which demonstrates the importance of HCI.
KW - HCI
KW - P-glycoprotein inhibitors
KW - Pharmacokinetic parameters
KW - Phenytoin
KW - WinNonlin software
KW - compartmental models
UR - http://www.scopus.com/inward/record.url?scp=85126468118&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85126468118
T3 - CEUR Workshop Proceedings
SP - 143
EP - 154
BT - CITIE 2020 - Proceedings of the 3rd Congreso Internacional de Tendencias en Innovacion Educativa 2020
A2 - Villalba-Condori, Klinge Orlando
A2 - Lavonen, Jari
A2 - Wong, Lung Hsiang
A2 - Yadav, Aman
PB - CEUR-WS
Y2 - 9 December 2020 through 11 December 2020
ER -