The use of peptides for immunodiagnosis of human Chagas disease

Anna Julia Ribeiro, Kamila Alves Silva, Lucas da Silva Lopes, Carlos Ananias Aparecido Resende, Carolina Alves Petit Couto, Isadora Braga Gandra, Isabela Amorim Gonçalves Pereira, Isabelle Caroline Dos Santos Barcelos, Sabrina Paula Pereira, Sandra Rodrigues Xavier, Grasiele de Sousa Viera Tavares, Juliana Martins Machado, Mariana Campos Da Paz, Miguel Angel Chávez-Fumagalli, Eduardo Antonio Ferraz Coelho, Rodolfo Cordeiro Giunchetti, Ana Thereza Chaves, Walderez Ornelas Dutra, Ana Alice Maia Gonçalves, Alexsandro Sobreira Galdino

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Chagas disease, caused by the protozoa Trypanosoma cruzi, continues to be a serious public health problem in Latin America, worsened by the limitations in its detection. Given the importance of developing new diagnostic methods for this disease, the present review aimed to verify the number of publications dedicated to research on peptides that demonstrate their usefulness in serodiagnosis. To this end, a bibliographic survey was conducted on the PubMed platform using the keyword “peptide” or “epitope” combined with “Chagas disease” or “Trypanosoma cruzi”; “diagno*” or “serodiagnosis” or “immunodiagnosis”, without period restriction. An increasing number of publications on studies employing peptides in ELISA and rapid tests assays was verified, which confirms the expansion of research in this field. It is possible to observe that many of the peptides tested so far originate from proteins widely used in the diagnosis of Chagas, and many of them are part of commercial tests developed. In this sense, as expected, promising results were obtained for several peptides when tested in ELISA, as many of them exhibited sensitivity and specificity values above 90%. Furthermore, some peptides have been tested in several studies, confirming their diagnostic potential. Despite the promising results observed, it is possible to emphasize the need for extensive testing of peptides, using different serological panels, in order to confirm their potential. The importance of producing an effective assay capable of detecting the clinical stages of the disease, as well as new immunogenic antigens that enable new serological diagnostic tools for Chagas disease, is evident.

Idioma originalInglés
Número de artículo35
PublicaciónAmino Acids
EstadoPublicada - dic. 2024


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