TY - JOUR
T1 - The intrahippocampal infusion of crotamine from Crotalus durissus terrificus venom enhances memory persistence in rats
AU - Vargas, Liane S.
AU - Lara, Marcus V.S.
AU - Gonçalves, Rithiele
AU - Mandredini, Vanusa
AU - Ponce-Soto, Luis Alberto
AU - Marangoni, Sergio
AU - Dal Belo, Cháriston A.
AU - Mello-Carpes, Pâmela B.
N1 - Funding Information:
This study was supported by Federal University of Pampa ( 01/2013 , Research's Groups Grant). L. Vargas was supported by CAPES student scholarship . M.V. Lara and R. Gonçalves were supported by Federal University of Pampa scholarship. We thank Ms. Aline Vieira for the artwork of Fig. 2 .
PY - 2014/7
Y1 - 2014/7
N2 - Previous research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory.
AB - Previous research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory.
KW - Inhibitory avoidance memory
KW - Object recognition memory
KW - Snake venom
KW - Toxin
UR - http://www.scopus.com/inward/record.url?scp=84901276092&partnerID=8YFLogxK
U2 - 10.1016/j.toxicon.2014.04.017
DO - 10.1016/j.toxicon.2014.04.017
M3 - Article
C2 - 24813333
AN - SCOPUS:84901276092
SN - 0041-0101
VL - 85
SP - 52
EP - 58
JO - Toxicon
JF - Toxicon
ER -