Strychnos pseudoquina and its purified compounds present an effective in vitro antileishmanial activity

Paula Sousa Lage, Pedro Henrique Rocha De Andrade, Amanda De Santana Lopes, Miguel Angel Chávez Fumagalli, Diogo Garcia Valadares, Mariana Costa Duarte, Daniela Pagliara Lage, Lourena Emanuele Costa, Vivian Tamietti Martins, Tatiana Gomes Ribeiro, José Dias De Souza Filho, Carlos Alberto Pereira Tavares, Rodrigo Maia De Pádua, João Paulo Viana Leite, Eduardo Antonio Ferraz Coelho

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31 Citas (Scopus)

Resumen

The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity of Strychnos pseudoquina St. Hil. was investigated and pure compounds that presented this biological effect were isolated. An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazonensis. A bioactivity-guided fractionation was performed, and two flavonoids were identified, quercetin 3-O-methyl ether and strychnobiflavone, which presented an effective antileishmanial activity against L. amazonensis, and studies were extended to establish their minimum inhibitory concentrations (IC50), their leishmanicidal effects on the intra-macrophage Leishmania stage, as well as their cytotoxic effects on murine macrophages (CC50), and in O+ human red blood cells. The data presented in this study showed the potential of an ethyl acetate extract of S. pseudoquina, as well as two flavonoids purified from it, which can be used as a therapeutic alternative on its own, or in association with other drugs, to treat disease evoked by L. amazonensis.

Idioma originalInglés
Número de artículo304354
PublicaciónEvidence-based Complementary and Alternative Medicine
Volumen2013
DOI
EstadoPublicada - 2013
Publicado de forma externa

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