Origins of cell selectivity of cationic steroid antibiotics

Bangwei Ding, Ning Yin, Yang Liu, Jaime Cardenas-Garcia, Richard Evanson, Thomas Orsak, Mingjin Fan, Gracija Turin, Paul B. Savage

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

76 Citas (Scopus)

Resumen

A key factor in the potential clinical utility of membrane-active antibiotics is their cell selectivity (i.e., prokaryote over eukaryote). Cationic steroid antibiotics were developed to mimic the lipid A binding character of polymyxin B and are shown to bind lipid A derivatives with affinity greater than that of polymyxin B. The outer membranes of Gram-negative bacteria are comprised primarily of lipid A, and a fluorophore-appended cationic steroid antibiotic displays very high selectivity for Gram-negative bacterial membranes over Gram-positive bacteria and eukaryotic cell membranes. This cell selectivity of cationic steroid antibiotics may be due, in part, to the affinity of these compounds for lipid A.

Idioma originalInglés
Páginas (desde-hasta)13642-13648
Número de páginas7
PublicaciónJournal of the American Chemical Society
Volumen126
N.º42
DOI
EstadoPublicada - 27 oct. 2004
Publicado de forma externa

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