New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment

Miguel Angel Chávez-Fumagalli, Tatiana Gomes Ribeiro, Rachel Oliveira Castilho, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Cecília Steinberg Perilo Coelho, Débora Vasconcelos Costa Mendonça, Manuel Soto, Carlos Alberto Pereira Tavares, André Augusto Gomes Faraco, Eduardo Antonio Ferraz Coelho

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

69 Citas (Scopus)

Resumen

Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization. It is a life-threatening disease of medical, social and economic importance in endemic areas. No vaccine is yet available for human use, and chemotherapy presents several problems. Pentavalent antimonials have been the drugs of choice to treat the disease for more than six decades; however, they exhibit high toxicity and are not indicated for children, for pregnant or breastfeeding women or for chronically ill patients. Amphotericin B (AmpB) is a second-line drug, and although it has been increasingly used to treat visceral leishmaniasis (VL), its clinical use has been hampered due to its high toxicity. This review focuses on the development and in vivo usage of new delivery systems for AmpB that aim to decrease its toxicity without altering its therapeutic efficacy. These new formulations, when adjusted with regard to their production costs, may be considered new drug delivery systems that promise to improve the treatment of leishmaniasis, by reducing the side effects and the number of doses while permitting a satisfactory cost-benefit ratio.

Idioma originalInglés
Páginas (desde-hasta)235-242
Número de páginas8
PublicaciónRevista da Sociedade Brasileira de Medicina Tropical
Volumen48
N.º3
DOI
EstadoPublicada - 27 jun. 2015
Publicado de forma externa

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