Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial

Donald L. Chi, Graciela Zegarra, Elsa C.Vasquez Huerta, Jorge L. Castillo, Peter Milgrom, Marilyn C. Roberts, Ailin R. Cabrera-Matta, Lloyd Mancl, Ana P. Merino

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

6 Citas (Scopus)

Resumen

Purpose: To evaluate the efficacy of xylitol-sweetened milk as a caries-preventive strategy. Methods: In this nine-month prospective proof-of-principle trial, Peruvian schoolchildren were randomized to one of five different milk groups: (1) eight g of xylitol per 200 mL milk once per day; (2) four g of xylitol per 100 mL milk twice per day; (3) eight g of sorbitol per 200 mL milk once per day; (4) four g of sorbitol per 100 mL milk twice per day; or (5) eight g of sucrose per 200 mL milk once per day. The primary outcome was plaque mutans streptococci (MS) at nine months. A secondary outcome was caries incidence. We hypothesized that children in the xylitol groups would have a greater MS decline and lower caries incidence. Results: One hundred fifty-three children were randomized in the intent-to-treat analyses. Children receiving xylitol had a greater decline in MS than children receiving sucrose (P=0.02) but were not different from children receiving sorbitol (P=0.07). Dental caries incidence for xylitol once per day or twice per day was 5.3±3.4 and 4.3±4.0 surfaces, respectively, compared to sorbitol once per day, sorbitol twice per day, or sucrose (4.1±2.8, 3.7±4.2, and 3.2±3.4 surfaces, respectively). There were no differences in caries incidence between xylitol and sucrose (rate ratio [RR] = 1.51; 95 percent confidence interval [CI] = 0.88, 2.59; P=0.13) or between xylitol and sorbitol (RR = 1.28; 95 percent CI = 0.90, 1.83; P=0.16). Conclusion: Xylitol-sweetened milk significantly reduced mutans streptococci levels compared to sucrose-sweetened milk, but differences in caries incidence were not detected.

Idioma originalInglés
Páginas (desde-hasta)152-160
Número de páginas9
PublicaciónJournal of Dentistry for Children
Volumen83
N.º3
EstadoPublicada - set. 2016

Huella

Profundice en los temas de investigación de 'Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial'. En conjunto forman una huella única.

Citar esto