TY - JOUR
T1 - Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application
AU - Aubert-Viard, François
AU - Mogrovejo-Valdivia, Alejandra
AU - Tabary, Nicolas
AU - Maton, Mickael
AU - Chai, Feng
AU - Neut, Christel
AU - Martel, Bernard
AU - Blanchemain, Nicolas
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/7
Y1 - 2019/7
N2 - The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) (PET) of the dressing was first modified by chitosan (CHT) crosslinked with genipin (Gpn). Parameters such as the concentration of reagents (Gpn and CHT) but also the crosslinking time and the working temperature were optimized to reach the maximal positive charges surface density. This support was then treated by the layer-by-layer (LbL) deposition of a multilayer system composed of methyl-beta-cyclodextrin polymer (PCD) (anionic) and CHT (cationic). After a thermal treatment to stabilize the LbL film, the textiles were loaded with CHX as antiseptic agent. The influence of the thermal treatment i) on the cytocompatibility, ii) on the degradation of the multilayer system, iii) on CHX sorption and release profiles and iv) on the antibacterial activity of the loaded textiles was studied.
AB - The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) (PET) of the dressing was first modified by chitosan (CHT) crosslinked with genipin (Gpn). Parameters such as the concentration of reagents (Gpn and CHT) but also the crosslinking time and the working temperature were optimized to reach the maximal positive charges surface density. This support was then treated by the layer-by-layer (LbL) deposition of a multilayer system composed of methyl-beta-cyclodextrin polymer (PCD) (anionic) and CHT (cationic). After a thermal treatment to stabilize the LbL film, the textiles were loaded with CHX as antiseptic agent. The influence of the thermal treatment i) on the cytocompatibility, ii) on the degradation of the multilayer system, iii) on CHX sorption and release profiles and iv) on the antibacterial activity of the loaded textiles was studied.
KW - Antibacterial textile
KW - Chitosan
KW - Chlorhexidine
KW - Cyclodextrin
KW - Cytocompatibility
KW - Genipin
KW - Layer-by-layer
UR - http://www.scopus.com/inward/record.url?scp=85062857223&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2019.03.044
DO - 10.1016/j.msec.2019.03.044
M3 - Article
C2 - 30948092
AN - SCOPUS:85062857223
SN - 0928-4931
VL - 100
SP - 554
EP - 563
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -