Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol

Julio Rubio, Sandra Yucra, Manuel Gasco, Gustavo F. Gonzales

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42 Citas (Scopus)

Resumen

Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a doseresponse effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65g pyrogallol/100g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a doseresponse manner due, in part, to its content of polyphenolic compounds.

Idioma originalInglés
Páginas (desde-hasta)628-634
Número de páginas7
PublicaciónToxicology Mechanisms and Methods
Volumen21
N.º8
DOI
EstadoPublicada - oct. 2011
Publicado de forma externa

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