Can molecular mimicry explain the cytokine storm of SARS-CoV-2? An in silico approach

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Resumen

PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.

Idioma originalInglés
Páginas (desde-hasta)5350-5357
Número de páginas8
PublicaciónJournal of Medical Virology
Volumen93
N.º9
DOI
EstadoPublicada - set. 2021

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