Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models

Lena Galvez Ranilla, Young In Kwon, Maria Ines Genovese, Franco Maria Lajolo, Kalidas Shetty

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

57 Citas (Scopus)

Resumen

Commonly consumed carbohydrate sweeteners derived from sugar cane, palm, and corn (syrups) were investigated to determine their potential to inhibit key enzymes relevant to Type 2 diabetes and hypertension based on the total phenolic content and antioxidant activity using in vitro models. Among sugar cane derivatives, brown sugars showed higher antidiabetes potential than white sugars; nevertheless, no angiotensin I-converting enzyme (ACE) inhibition was detected in both sugar classes. Brown sugar from Peru and Mauritius (dark muscovado) had the highest total phenolic content and 1,1-diphenyl-2- picrylhydrazyl radical scavenging activity, which correlated with a moderate inhibition of yeast α-glucosidase without showing a significant effect on porcine pancreatic α-amylase activity. In addition, chlorogenic acid quantified by high-performance liquid chromatography was detected in these sugars (128 ± 6 and 144 ± 2 μg/g of sample weight, respectively). Date sugar exhibited high α-glucosidase, α-amylase, and ACE inhibitory activities that correlated with high total phenolic content and antioxidant activity. Neither phenolic compounds or antioxidant activity was detected in corn syrups, indicating that nonphenolic factors may be involved in their significant ability to inhibit α-glucosidase, α-amylase, and ACE. This study provides a strong biochemical rationale for further in vivo studies and useful information to make better dietary sweetener choices for Type 2 diabetes and hypertension management.

Idioma originalInglés
Páginas (desde-hasta)337-348
Número de páginas12
PublicaciónJournal of Medicinal Food
Volumen11
N.º2
DOI
EstadoPublicada - 1 jun. 2008
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models'. En conjunto forman una huella única.

Citar esto