TY - JOUR
T1 - A calix[4]arene derivative and its selective interaction with drugs (clofibric acid, diclofenac and aspirin)
AU - Danil de Namor, Angela F.
AU - Al Nuaim, Maan
AU - Villanueva Salas, Jose A.
AU - Bryant, Sophie
AU - Howlin, Brendan
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/3/30
Y1 - 2017/3/30
N2 - The synthesis and characterisation of a partially substituted calix[4]arene, namely, 5,11,17,23-tetra-tert-butyl,25,27-bis[aminoethoxy] 26,28-dihydroxycalix[4]arene are reported. Its interaction with commonly used pharmaceuticals (clofibric acid, diclofenac and aspirin) was investigated by spectroscopic (1H NMR and UV), electrochemical (conductance measurements) and thermal (titration calorimetry) techniques. It is concluded on the basis of the experimental work and molecular simulation studies that the receptor interacts selectively with these drugs. Preliminary studies on the selective extraction of these pharmaceuticals from water by the calix receptor are reported and the potential for a carrier mediated sensor based on this ligand for ‘on site’ monitoring of pharmaceuticals is discussed.
AB - The synthesis and characterisation of a partially substituted calix[4]arene, namely, 5,11,17,23-tetra-tert-butyl,25,27-bis[aminoethoxy] 26,28-dihydroxycalix[4]arene are reported. Its interaction with commonly used pharmaceuticals (clofibric acid, diclofenac and aspirin) was investigated by spectroscopic (1H NMR and UV), electrochemical (conductance measurements) and thermal (titration calorimetry) techniques. It is concluded on the basis of the experimental work and molecular simulation studies that the receptor interacts selectively with these drugs. Preliminary studies on the selective extraction of these pharmaceuticals from water by the calix receptor are reported and the potential for a carrier mediated sensor based on this ligand for ‘on site’ monitoring of pharmaceuticals is discussed.
KW - Aspirin
KW - Calixarenes
KW - Clofibric acid
KW - Diclofenac
KW - Pharmaceuticals
KW - Thermodynamics
UR - http://www.scopus.com/inward/record.url?scp=85009180974&partnerID=8YFLogxK
U2 - 10.1016/j.ejps.2016.12.027
DO - 10.1016/j.ejps.2016.12.027
M3 - Article
C2 - 28063965
AN - SCOPUS:85009180974
SN - 0928-0987
VL - 100
SP - 1
EP - 8
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
ER -