5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local β adrenoceptors

Maria Cláudia G. Oliveira-Fusaro, Juliana Trindade Clemente-Napimoga, Juliana Maia Teixeira, Karla Elena Torres-Chávez, Carlos Amílcar Parada, Cláudia Herrera Tambeli

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

The 5-hydroxytryptamine (serotonin, 5-HT) is an important inflammatory mediator found in high levels in the synovial fluid of the temporomandibular joint (TMJ) of patients with inflammatory pain. In this study, we used the nociceptive behavior responses, measured as flinching the head and rubbing the orofacial region, as a nociceptive assay. We demonstrated that the local blockade of the 5-HT3 receptor and β1 or β2-adrenoceptors, the depletion of norepinephrine in the sympathetic terminals and the local inhibition of cyclooxygenase significantly reduced 5-HT-induced TMJ nociception. These results demonstrated that 5-HT induces nociception in the TMJ region by the activation of β1 and β2 adrenoceptors located in the TMJ region and local release of sympathetic amines and prostaglandins. Therefore, the high levels of 5-HT in the synovial fluid of patients with TMJ inflammatory pain may contribute to TMJ pain by similar mechanisms.

Idioma originalInglés
Páginas (desde-hasta)458-464
Número de páginas7
PublicaciónPharmacology Biochemistry and Behavior
Volumen102
N.º3
DOI
EstadoPublicada - set. 2012
Publicado de forma externa

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