Usability Experience in the Calculation of Pharmacokinetic Parameters with Software: Phenytoin Case

Stefhano Olivo Valdivia, Rita Nieto Montesinos, Karim Vera López, Gonzalo Dávila-Del-Carpio

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The objective of this research was to evaluate how the use of mathematical models that simulate the drug's pharmacokinetic, can influence the calculation of pharmacokinetic parameters, being the human-computer-interaction an useful tool to simplify them. For it, we study the effect of P-gp inhibitors on the pharmacokinetics of the anticonvulsant, phenytoin; we co-administered the drugs to a group of rats and then measured the plasma concentrations of phenytoin, from which we calculated the pharmacokinetic parameters, manually and using the WinNonlin software. P-gp inhibitors caused a change in the pharmacokinetics of phenytoin, moving from the open-one compartment model to the open-two-compartment model, this was demonstrated with a better fit of data (r = 0.9871) in the two compartments model. Since complex mathematical models are necessary, the software will be useful, but it is the pharmacokinetic specialists who evaluate and define the model to be used, which demonstrates the importance of HCI.

Original languageEnglish
Title of host publicationCITIE 2020 - Proceedings of the 3rd Congreso Internacional de Tendencias en Innovacion Educativa 2020
EditorsKlinge Orlando Villalba-Condori, Jari Lavonen, Lung Hsiang Wong, Aman Yadav
PublisherCEUR-WS
Pages143-154
Number of pages12
ISBN (Electronic)9786124443275
StatePublished - 2020
Event3rd Congreso Internacional de Tendencias en Innovacion Educativa, CITIE 2020 - 3rd International Conference on Trends in Educational Innovation, CITIE 2020 - Arequipa, Peru
Duration: 9 Dec 202011 Dec 2020

Publication series

NameCEUR Workshop Proceedings
Volume3099
ISSN (Print)1613-0073

Conference

Conference3rd Congreso Internacional de Tendencias en Innovacion Educativa, CITIE 2020 - 3rd International Conference on Trends in Educational Innovation, CITIE 2020
Country/TerritoryPeru
CityArequipa
Period9/12/2011/12/20

Keywords

  • HCI
  • P-glycoprotein inhibitors
  • Pharmacokinetic parameters
  • Phenytoin
  • WinNonlin software
  • compartmental models

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