Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy

Eduardo Antonio Ferraz Coelho, Miguel Angel Chávez-Fumagalli, Lourena Emanuele Costa, Carlos Alberto Pereira Tavares, Manuel Soto, Luiz Ricardo Goulart

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Phage display is a high-throughput subtractive proteomic technology used for the generation and screening of large peptide and antibody libraries. It is based on the selection of phage-fused surface-exposed peptides that recognize specific ligands and demonstrate desired functionality for diagnostic and therapeutic purposes. Phage display has provided unmatched tools for controlling viral, bacterial, fungal, and parasitic infections, and allowed identification of new therapeutic targets to treat cancer, metabolic diseases, and other chronic conditions. This review presents recent advancements in serodiagnostics and prevention of leishmaniasis -an important tropical parasitic disease- achieved using phage display for the identification of novel antigens with improved sensitivity and specificity. Our focus is on theranostics of visceral leishmaniasis with the aim to develop biomarker candidates exhibiting both diagnostic and therapeutic potential to fight this important, yet neglected, tropical disease.

Original languageEnglish
Pages (from-to)370-379
Number of pages10
JournalRevista da Sociedade Brasileira de Medicina Tropical
Volume48
Issue number4
DOIs
StatePublished - 1 Jul 2015
Externally publishedYes

Keywords

  • Mimotopes
  • Phage display
  • Serodiagnosis
  • Vaccine
  • Visceral leishmaniasis

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