The intrahippocampal infusion of crotamine from Crotalus durissus terrificus venom enhances memory persistence in rats

Liane S. Vargas, Marcus V.S. Lara, Rithiele Gonçalves, Vanusa Mandredini, Luis Alberto Ponce-Soto, Sergio Marangoni, Cháriston A. Dal Belo, Pâmela B. Mello-Carpes

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Previous research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalToxicon
Volume85
DOIs
StatePublished - Jul 2014
Externally publishedYes

Keywords

  • Inhibitory avoidance memory
  • Object recognition memory
  • Snake venom
  • Toxin

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