Evaluation of antihyperglycemia and antihypertension potential of native Peruvian fruits using in vitro models

Marcia Da Silva Pinto, Lena Galvez Ranilla, Emmanouil Apostolidis, Franco Maria Lajolo, Maria Inés Genovese, Kalidas Shetty

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Local food diversity and traditional crops are essential for cost-effective management of the global epidemic of type 2 diabetes and associated complications of hypertension. Water and 12 ethanol extracts of native Peruvian fruits such as Lucuma (Pouteria lucuma), Pacae (Inga feuille), Papayita arequipeña (Carica pubescens), Capuli (Prunus capuli), Aguaymanto (Physalis peruviana), and Algarrobo (Prosopis pallida) were evaluated for total phenolics, antioxidant activity based on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay, and functionality such as in vitro inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension linked to type 2 diabetes. The total phenolic content ranged from 3.2 (Aguaymanto) to 11.4 (Lucuma fruit) mg/g of sample dry weight. A significant positive correlation was found between total phenolic content and antioxidant activity for the ethanolic extracts. No phenolic compound was detected in Lucuma (fruit and powder) and Pacae. Aqueous extracts from Lucuma and Algarrobo had the highest α-glucosidase inhibitory activities. Papayita arequipeña and Algarrobo had significant ACE inhibitory activities reflecting antihypertensive potential. These in vitro results point to the excellent potential of Peruvian fruits for food-based strategies for complementing effective antidiabetes and antihypertension solutions based on further animal and clinical studies.

Original languageEnglish
Pages (from-to)278-291
Number of pages14
JournalJournal of Medicinal Food
Issue number2
StatePublished - 1 Apr 2009
Externally publishedYes


  • Angiotensin-converting enzyme
  • Antioxidant activity
  • Enzyme inhibition
  • Hyperglycemia
  • Hypertension
  • Peruvian fruits
  • Phenolic phytochemicals
  • Type 2 diabetes
  • α-amylase
  • α-glucosidase


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