Can molecular mimicry explain the cytokine storm of SARS-CoV-2? An in silico approach

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8 Scopus citations

Abstract

PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.

Original languageEnglish
Pages (from-to)5350-5357
Number of pages8
JournalJournal of Medical Virology
Volume93
Issue number9
DOIs
StatePublished - Sep 2021

Keywords

  • SARS-CoV-2
  • cytokine storm
  • macrophage
  • molecular mimicry

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