Abstract
PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.
Original language | English |
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Pages (from-to) | 5350-5357 |
Number of pages | 8 |
Journal | Journal of Medical Virology |
Volume | 93 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2021 |
Keywords
- SARS-CoV-2
- cytokine storm
- macrophage
- molecular mimicry