Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models

Lena Galvez Ranilla, Young In Kwon, Maria Ines Genovese, Franco Maria Lajolo, Kalidas Shetty

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Commonly consumed carbohydrate sweeteners derived from sugar cane, palm, and corn (syrups) were investigated to determine their potential to inhibit key enzymes relevant to Type 2 diabetes and hypertension based on the total phenolic content and antioxidant activity using in vitro models. Among sugar cane derivatives, brown sugars showed higher antidiabetes potential than white sugars; nevertheless, no angiotensin I-converting enzyme (ACE) inhibition was detected in both sugar classes. Brown sugar from Peru and Mauritius (dark muscovado) had the highest total phenolic content and 1,1-diphenyl-2- picrylhydrazyl radical scavenging activity, which correlated with a moderate inhibition of yeast α-glucosidase without showing a significant effect on porcine pancreatic α-amylase activity. In addition, chlorogenic acid quantified by high-performance liquid chromatography was detected in these sugars (128 ± 6 and 144 ± 2 μg/g of sample weight, respectively). Date sugar exhibited high α-glucosidase, α-amylase, and ACE inhibitory activities that correlated with high total phenolic content and antioxidant activity. Neither phenolic compounds or antioxidant activity was detected in corn syrups, indicating that nonphenolic factors may be involved in their significant ability to inhibit α-glucosidase, α-amylase, and ACE. This study provides a strong biochemical rationale for further in vivo studies and useful information to make better dietary sweetener choices for Type 2 diabetes and hypertension management.

Original languageEnglish
Pages (from-to)337-348
Number of pages12
JournalJournal of Medicinal Food
Issue number2
StatePublished - 1 Jun 2008
Externally publishedYes


  • Angiotensin I-converting enzyme inhibitor
  • Antioxidant activity
  • Cane sugars
  • Corn syrups
  • Hypertension
  • Palm sugars
  • Phenolics
  • Type 2 diabetes
  • α-amylase inhibitor
  • α-glucosidase inhibitor


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