TY - JOUR
T1 - Alzheimer's Disease
T2 - A Silent Pandemic-A Systematic Review on the Situation and Patent Landscape of the Diagnosis
AU - Goyzueta-Mamani, Luis Daniel
AU - Chávez-Fumagalli, Miguel Angel
AU - Alvarez-Fernandez, Karla
AU - Aguilar-Pineda, Jorge A.
AU - Nieto-Montesinos, Rita
AU - Del-Carpio, Gonzalo Davila
AU - Vera-Lopez, Karin J.
AU - Cardenas, Christian L.Lino
N1 - Publisher Copyright:
© 2022 Bentham Science Publishers.
PY - 2022/12
Y1 - 2022/12
N2 - Background: Alzheimer's disease (AD) is characterized by cognitive impairment, tau protein deposits, and amyloid beta plaques. AD impacted 44 million people in 2016, and it is estimated to affect 100 million people by 2050. AD is disregarded as a pandemic compared with other diseases. To date, there is no effective treatment or diagnosis. Objective: We aimed to discuss the current tools used to diagnose COVID-19, point out their potential to be adapted for AD diagnosis, and review the landscape of existing patents in the AD field and future perspectives for AD diagnosis. Methods: We carried out a scientific screening following a research strategy in PubMed; Web of Science; the Derwent Innovation Index; the KCI-Korean Journal Database; SciELO; the Russian Science Citation index; and the CDerwent, EDerwent, and MDerwent index databases. Results: A total of 326 from 6,446 articles about AD and 376 from 4,595 articles about COVID-19 were analyzed. Of these, AD patents were focused on biomarkers and neuroimaging with no accurate, validated diagnostic methods, and only 7% of kit development patents were found. In comparison, COVID-19 patents were 60% about kit development for diagnosis; they are highly accurate and are now commercialized. Conclusion: AD is still neglected and not recognized as a pandemic that affects the people and economies of all nations. There is a gap in the development of AD diagnostic tools that could be filled if the interest and effort that has been invested in tackling the COVID-19 emergency could also be applied for innovation.
AB - Background: Alzheimer's disease (AD) is characterized by cognitive impairment, tau protein deposits, and amyloid beta plaques. AD impacted 44 million people in 2016, and it is estimated to affect 100 million people by 2050. AD is disregarded as a pandemic compared with other diseases. To date, there is no effective treatment or diagnosis. Objective: We aimed to discuss the current tools used to diagnose COVID-19, point out their potential to be adapted for AD diagnosis, and review the landscape of existing patents in the AD field and future perspectives for AD diagnosis. Methods: We carried out a scientific screening following a research strategy in PubMed; Web of Science; the Derwent Innovation Index; the KCI-Korean Journal Database; SciELO; the Russian Science Citation index; and the CDerwent, EDerwent, and MDerwent index databases. Results: A total of 326 from 6,446 articles about AD and 376 from 4,595 articles about COVID-19 were analyzed. Of these, AD patents were focused on biomarkers and neuroimaging with no accurate, validated diagnostic methods, and only 7% of kit development patents were found. In comparison, COVID-19 patents were 60% about kit development for diagnosis; they are highly accurate and are now commercialized. Conclusion: AD is still neglected and not recognized as a pandemic that affects the people and economies of all nations. There is a gap in the development of AD diagnostic tools that could be filled if the interest and effort that has been invested in tackling the COVID-19 emergency could also be applied for innovation.
KW - Alzheimer's disease
KW - COVID-19
KW - biomarkers
KW - diagnostic tools
KW - patent
KW - silent pandemic
UR - http://www.scopus.com/inward/record.url?scp=85138107583&partnerID=8YFLogxK
U2 - 10.2174/1872208316666220408114129
DO - 10.2174/1872208316666220408114129
M3 - Review article
C2 - 35400333
AN - SCOPUS:85138107583
SN - 1872-2083
VL - 16
SP - 355
EP - 378
JO - Recent Patents on Biotechnology
JF - Recent Patents on Biotechnology
IS - 4
ER -